Your brain can still make new neurons when you’re an adult. But how does the rare birth of these new neurons contribute to cognitive function?

Neurons are the cells that govern brain function, and you are born with most of the neurons you will ever have during your lifetime. While the brain undergoes most of its development during early life, specific regions of the brain continue to generate new neurons throughout adulthood, although at a much lower rate. Whether this process of neurogenesis actually happens in adults and what function it serves in the brain is still a subject of debate among scientists.

Past research has shown that people with epilepsy or Alzheimer’s disease and other dementias develop fewer neurons as adults than people without these conditions. However, whether the absence of new neurons contributes to the cognitive challenges patients with these neurological disorders face is unknown.

We are part of a team of stem cell researchers, neuroscientists, neurologists, neurosurgeons and neuropsychologists. Our newly published research reveals that the new neurons that form in adults’ brains are linked to how you learn from listening to other people.

New neurons and learning

Researchers know that new neurons contribute to memory and learning in mice. But in humans, the technical challenges of identifying and analyzing new neurons in adult brains, combined with their rarity, had led scientists to doubt their significance to brain function.

To uncover the relationship between neurogenesis in adults and cognitive function, we studied patients with drug-resistant epilepsy. These patients underwent cognitive assessments prior to and donated brain tissue during surgical procedures to treat their seizures. To see whether how many new neurons a patient had was associated with specific cognitive functions, we looked under the microscope for markers of neurogenesis.

We found that new neurons in the adult brain are linked to reduced cognitive decline – particularly in verbal learning, or learning by listening to others.

This was very surprising to us. In mice, new neurons are known for their role in helping them learn and navigate new spaces through visual exploration. However, we did not observe a similar connection between new neurons and spatial learning in people.

Improving cognition

Talking with others and remembering those conversations is an integral part of day-to-day life for many people. However, this crucial cognitive function declines with age, and the effects are more severe with neurological disorders. As aging populations grow, the burden of cognitive decline on health care systems worldwide will increase.

Our research suggests that the link between newborn neurons and verbal learning may be foundational to developing treatments to restore cognition in people. Enhancing new neuron generation could be a potential strategy to improve brain health and restore cognition in aging and in people with epilepsy or dementia. But for now, these ideas are just goals and any future treatments are a long way off.

Importantly, our finding that new neurons function differently in mice and in humans emphasizes the critical need to study biological functions like neurogenesis in people whenever possible. This will ensure that research conducted in animal models, such as mice, is relevant to people and can translate to the clinic.

Current drugs for epilepsy primarily aim to reduce seizures, with limited focus on addressing the cognitive decline patients experience. To enhance cognitive outcomes for patients, we started a clinical trial focusing on boosting new neuron production and cognition in epilepsy patients through aerobic exercise. We are currently in the early Phase 1 of the clinical trial, which seeks to establish the safety of the study. Thus far, two patients have successfully and safely finished the study. We plan to recruit eight more patients to exercise and complete this phase.

By bringing together basic science in the lab and clinical research in people, a better understanding of brain regeneration could help support brain health throughout the lifespan.

Aswathy Ammothumkandy, Postdoctoral Research Associate in Stem Cell Biology and Regenerative Medicine, University of Southern California; Charles Liu, Professor of Clinical Neurological Surgery, University of Southern California, and Michael A. Bonaguidi, Associate Professor of Stem Cell Biology and Regenerative Medicine, University of Southern California

This article is republished from The Conversation under a Creative Commons license. Read the original article.

We have only one example of biology forming in the universe – life on Earth. But what if life can form in other ways? How do you look for alien life when you don’t know what alien life might look like?

These questions are preoccupying astrobiologists, who are scientists who look for life beyond Earth. Astrobiologists have attempted to come up with universal rules that govern the emergence of complex physical and biological systems both on Earth and beyond.

I’m an astronomer who has written extensively about astrobiology. Through my research, I’ve learned that the most abundant form of extraterrestrial life is likely to be microbial, since single cells can form more readily than large organisms. But just in case there’s advanced alien life out there, I’m on the international advisory council for the group designing messages to send to those civilizations.

Detecting life beyond Earth

Since the first discovery of an exoplanet in 1995, over 5,000 exoplanets, or planets orbiting other stars, have been found.

Many of these exoplanets are small and rocky, like Earth, and in the habitable zones of their stars. The habitable zone is the range of distances between the surface of a planet and the star it orbits that would allow the planet to have liquid water, and thus support life as we on Earth know it.

The sample of exoplanets detected so far projects 300 million potential biological experiments in our galaxy – or 300 million places, including exoplanets and other bodies such as moons, with suitable conditions for biology to arise.

The uncertainty for researchers starts with the definition of life. It feels like defining life should be easy, since we know life when we see it, whether it’s a flying bird or a microbe moving in a drop of water. But scientists don’t agree on a definition, and some think a comprehensive definition might not be possible.

NASA defines life as a “self-sustaining chemical reaction capable of Darwinian evolution.” That means organisms with a complex chemical system that evolve by adapting to their environment. Darwinian evolution says that the survival of an organism depends on its fitness in its environment.

The evolution of life on Earth has progressed over billions of years from single-celled organisms to large animals and other species, including humans.

Exoplanets are remote and hundreds of millions of times fainter than their parent stars, so studying them is challenging. Astronomers can inspect the atmospheres and surfaces of Earth-like exoplanets using a method called spectroscopy to look for chemical signatures of life.

Spectroscopy might detect signatures of oxygen in a planet’s atmosphere, which microbes called blue-green algae created by photosynthesis on Earth several billion years ago, or chlorophyll signatures, which indicate plant life.

NASA’s definition of life leads to some important but unanswered questions. Is Darwinian evolution universal? What chemical reactions can lead to biology off Earth?

Evolution and complexity

All life on Earth, from a fungal spore to a blue whale, evolved from a microbial last common ancestor about 4 billion years ago.

The same chemical processes are seen in all living organisms on Earth, and those processes might be universal. They also may be radically different elsewhere.

In October 2024, a diverse group of scientists gathered to think outside the box on evolution. They wanted to step back and explore what sort of processes created order in the universe – biological or not – to figure out how to study the emergence of life totally unlike life on Earth.

Two researchers present argued that complex systems of chemicals or minerals, when in environments that allow some configurations to persist better than others, evolve to store larger amounts of information. As time goes by, the system will grow more diverse and complex, gaining the functions needed for survival, through a kind of natural selection.

They speculated that there might be a law to describe the evolution of a wide variety of physical systems. Biological evolution through natural selection would be just one example of this broader law.

In biology, information refers to the instructions stored in the sequence of nucleotides on a DNA molecule, which collectively make up an organism’s genome and dictate what the organism looks like and how it functions.

If you define complexity in terms of information theory, natural selection will cause a genome to grow more complex as it stores more information about its environment.

Complexity might be useful in measuring the boundary between life and nonlife.

However, it’s wrong to conclude that animals are more complex than microbes. Biological information increases with genome size, but evolutionary information density drops. Evolutionary information density is the fraction of functional genes within the genome, or the fraction of the total genetic material that expresses fitness for the environment.

Organisms that people think of as primitive, such as bacteria, have genomes with high information density and so appear better designed than the genomes of plants or animals.

A universal theory of life is still elusive. Such a theory would include the concepts of complexity and information storage, but it would not be tied to DNA or the particular kinds of cells we find in terrestrial biology.

Implications for the search for extraterrestial life

Researchers have explored alternatives to terrestrial biochemistry. All known living organisms, from bacteria to humans, contain water, and it is a solvent that is essential for life on Earth. A solvent is a liquid medium that facilitates chemical reactions from which life could emerge. But life could potentially emerge from other solvents, too.

Astrobiologists Willam Bains and Sara Seager have explored thousands of molecules that might be associated with life. Plausible solvents include sulfuric acid, ammonia, liquid carbon dioxide and even liquid sulfur.

Alien life might not be based on carbon, which forms the backbone of all life’s essential molecules – at least here on Earth. It might not even need a planet to survive.

Advanced forms of life on alien planets could be so strange that they’re unrecognizable. As astrobiologists try to detect life off Earth, they’ll need to be creative.

One strategy is to measure mineral signatures on the rocky surfaces of exoplanets, since mineral diversity tracks terrestrial biological evolution. As life evolved on Earth, it used and created minerals for exoskeletons and habitats. The hundred minerals present when life first formed have grown to about 5,000 today.

For example, zircons are simple silicate crystals that date back to the time before life started. A zircon found in Australia is the oldest known piece of Earth’s crust. But other minerals, such as apatite, a complex calcium phosphate mineral, are created by biology. Apatite is a primary ingredient in bones, teeth and fish scales.

Another strategy to finding life unlike that on Earth is to detect evidence of a civilization, such as artificial lights, or the industrial pollutant nitrogen dioxide in the atmosphere. These are examples of tracers of intelligent life called technosignatures.

It’s unclear how and when a first detection of life beyond Earth will happen. It might be within the solar system, or by sniffing exoplanet atmospheres, or by detecting artificial radio signals from a distant civilization.

The search is a twisting road, not a straightforward path. And that’s for life as we know it – for life as we don’t know it, all bets are off.

Chris Impey, University Distinguished Professor of Astronomy, University of Arizona

This article is republished from The Conversation under a Creative Commons license. Read the original article.