The California Highway Patrol has confirmed two fatalities in the crash, which occurred on Highway 29 at Spruce Grove Road Extension shortly before 10:30 a.m
CHP reported one fatality when officials first arrived at the scene, with another person with major injuries.
Fire officials were attempting to extricate another victim as sheriff's officials responded.
The second death was confirmed at approximately 10:53 a.m.
The crash also blocked the roadway. Just after 11 a.m. officials opened the road with one-way traffic control, which was in effect for just over 40 minutes before the highway was once again opened. Tow services were summoned to remove vehicles from the scene.
CHP has so far not offered any other details on the specifics of the incident, including how many cars were involved and the identities of the victims.
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