The crash occurred at about 8 p.m. Friday near the Le Trianon Resort, according to the California Highway Patrol.
CHP, the Lake County Sheriff's Office and Northshore Fire were among the responders to the crash, which reports from the scene said involved more than one vehicle, one of which was overturned.
The blocked roadway didn't open up again until nearly 9 p.m.
In the mean time, a REACH helicopter transported one of the subjects to an area hospital, while two others went to Sutter Lakeside, the CHP reported.
Major injuries were reported, but the identify of the injured and specifics about their conditions were not available late Friday.
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