The crash occurred at approximately 3:17 p.m. on Highway 29 at the Main Street exit, according to California Highway Patrol Officer Dallas Richey.
Tammy Dias, 44, of Clearlake was driving her green 2005 Mazda Tribute northbound on Highway 29, approaching the Main Street exit in Kelseyville at approximately 55 miles per hour, Richey said.
Andrew Layton, 39, of Upper Lake, who was traveling in an orange 2007 Chevy HHR, turned southbound onto Highway from Main Street in Kelseyville. Richey said Layton turned into the northbound lane of Highway and collided head-on with the Mazda.
Richey said both drivers were transported by REACH air ambulance to Santa Rosa Memorial Hospital for treatment of major injuries.
Layton's two minor children sustained minor to moderate injuries and were transported by ambulance to Sutter Lakeside Hospital. The CHP said a 19-year-old female passenger from the Mazda sustained minor injuries but was not transported.
CHP Officer Mark Crutcher is investigating the crash.
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