The two-vehicle crash occurred on Highway 29 and Main Street in Kelseyville at around 3:19 p.m., according to reports from the California Highway Patrol.
Initial reports from the scene indicated as many as five people were injured in the wreck, which blocked the merging lane of traffic.
Kelseyville Fire Protection District – with mutual aid from Lakeport Fire Protection District – responded along with CHP and the Lake County Sheriff's Office, according to the CHP report.
In all, three people were transported to the hospital, with one of them taken via air ambulance out of the county, officials at the scene indicated.
The roadway was reported to be clear about an hour after the crash.
Family members reported that county resident Andy Layton and his two children were involved in the crash, but they had no updates on his condition.
Further details about the cause of the crash and the others involved in it were not available Monday evening.
Gary McAuley contributed to this report.
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