The first occurred near Blue Lakes shortly before 3:30 p.m., the second was reported on Highway 20 in Lucerne just after 8 p.m.
The Blue Lakes crash reportedly involved three vehicles, including a Chevrolet pickup, a Dodge SUV and a Chevrolet sedan, according to the California Highway Patrol. One of the vehicles had rolled over in the westbound lane.
A person was reported trapped in a vehicle, according to the initial CHP report.
The CHP reported that major injuries resulted, but the names of those involved were not immediately available.
Both lanes of traffic were blocked at CHP and firefighters responded to the scene. CHP reported that the roadway was reopened at approximately 4:44 p.m.
Later Friday, at 8:10 p.m. a vehicle was reported into a tree at Lucerne Harbor Park on Highway 20 at Ninth.
The collision also was reported to have resulted in major injuries, according to the CHP.
An air ambulance landed in Lucerne a short time later to transport the victim to an area hospital.
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