It was reported at about 4:45 p.m. Sunday at 24606 Highway 29 at Bradford Road near Middletown, according to the California Highway Patrol.
Two motorcycles were down blocking the roadway. The CHP report noted that another vehicle may have contributed to or caused the crash, but additional details weren't available late Sunday.
The highway was blocked until shortly before 5:30 p.m., when the CHP reported both lanes had been reopened.
The crash victims were reportedly transferred to Santa Rosa Memorial Hospital, but their identities and the extent of their injuries was not available from the CHP Sunday.
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