Officer Steve Tanguay of the Clear Lake Office of the California Highway Patrol confirmed that a death had resulted from the crash, which was reported shortly after 2:45 a.m. Wednesday.
A vehicle was reported off the roadway, with two subjects reportedly coming out of it, according to the CHP's initial reports.
Names of those involved was not yet available shortly before 10 a.m.
Traffic was blocked in both directions and Caltrans put a highway closure in place, according to the CHP.
A blood draw was conducted on one individual who was taken to Sutter Lakeside Hospital for treatment, the report stated.
Tow companies were called to tow vehicles for evidence, officials said.
Tanguay said the CHP will issue a full account of the crash shortly.
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