The California Highway Patrol reported that the crash occurred on Highway 29 just north of Kit's Corner at Highway 281 just after 10:30 p.m.
As a result of the crash a vehicle had rolled several times, the CHP reported.
The CHP reported a vehicle was off the road and into a ravine and two air ambulances were en route.
The roadway was closed both the directions, with Soda Bay Road being used as alternate access, according to the CHP. It was scheduled to reopen before midnight, with gravel being cleaned off of the road.
There was no word late Saturday about the extent of the injuries suffered by those involved.
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