The California Highway Patrol reported that the crash occurred on eastbound Highway 175 on the way to Cobb, one mile from Kelseyville, just after 1 p.m.
A motorcycle was reported to have gone off the road and into a nearby field, according to the CHP.
The CHP said another vehicle was involved. That vehicle had gone 20 feet off the roadway.
The collision resulted in both of the highway's lanes being blocked for emergency vehicles, the CHP said.
Officials said the roadway was reopened just a few minutes before 2 p.m.
The identities of those involved and the extent of their injuries was not available Saturday, although the CHP reported major injuries.
A CHP unit in Santa Rosa was dispatched to Santa Rosa Memorial Hospital to conduct a blood draw in the case.
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