The crash occurred at around 9:44 p.m. on Highway 29 just south of the Hopland Grade portion of Highway 175, the California Highway Patrol reported.
The CHP's Ukiah Dispatch Center confirmed early Saturday that the crash resulted in a death.
A vehicle was reported to have run through the intersection's stoplight and collided with another car, according to the CHP. One of the vehicles was reported to have caught fire after the crash.
Lakeport Fire shut down the roadway at 9:45 p.m., with CHP reported that the road wasn't fully reopened until midnight. In the meantime, traffic had to be rerouted around the crash site.
The crash victims were reported to have been taken to Santa Rosa Memorial Hospital by helicopter. It wasn't clear where a child who was in one of the vehicles was taken for treatment.
One of the crash victims was reported to have suffered major head injuries, a punctured lung and a broken femur.
Officials reported that the collision resulted in slippery conditions on the roadway, which had to be washed down.
The identities of the victims was not available Friday night.
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