The California Highway Patrol reported that the crash occurred just before 5 p.m. on westbound Highway 20 east of Walker Ridge Road, which is about 15 miles east of Clearlake Oaks.
Initial reports said the vehicle involved was an SUV, but it was later reported to be a four-door sedan.
Officials reported that the sedan was 50 to 75 feet off the side of the road, and a long cable was needed to secure the vehicle and recover it.
Two people were said to be involved, both complaining of back pain, according to officials.
Fire and medical crews responded to the scene, and REACH air ambulance was summoned for medical transport.
Initial reports indicated major injuries but no further information about the extent of injuries or the names of those involved was available late Monday.
Harold LaBonte contributed tot his report.
E-mail Elizabeth Larson at This email address is being protected from spambots. You need JavaScript enabled to view it..
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